ABCD

National Ph.D. Meeting

Salerno, Italy · 24-26 March 2022

SIBBM
ABCD
SIBBM

National Ph.D. Meeting

Salerno, Italy · 24-26 March 2022

Programme

  • 12:30-14:30

    Registration

    14:30-16:30

    Session 1 – Trafficking and Cell signaling

    14:30-14:50

    Flavia Martino (Candiolo, TO)
    Identification of RabGAP interactomes by proximity biotinylation

    14:50-15:10

    Gorana Jendrisek (Milan)
    Unraveling non-clathrin endocytosis: regulation and relevance in EGFR internalization

    15:10-15:30

    Daniele Viavattene (Turin)
    mTOR, STAT3 and IP3R3 interplay in the regulation of calcium homeostasis and apoptosis in breast cancer cells

    15:30-15:50

    Vittoria Nicolis di Robilant (Rome)
    Inactivation of the nijmegen breakage syndrome protein abrogates SHH-driven cerebellar development/tumorigenesis through the primary cilium

    15:50-16:10

    Francesco Farris (Milan)
    PMEL amyloid fibrils activate Agrin-HIPPO mediated mechano-transduction through ECM stiffening

    16:10-16:30

    Maria Concetta Sergio (Pozzuoli, NA)
    Role of E protein in the release of SARS-CoV-2 virions

    16:30-16:55

    Flash Presentations I

    16:30-16:35

    Deborah Salvi Mesa (Milan)
    Interorganelle contact sites regulate EGFR endocytosis

    16:35-16:40

    Simona Ricciardi (Pozzuoli, NA)
    The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

    16:40-16:45

    Giuseppe Fragale (Milan)
    Tuning translation in response to mechanical stimuli

    16:45-16:50

    Maria Iavazzo (Pozzuoli, NA)
    Transcriptional control of cargo selection during autophagy

    16:50-16:55

    Angelica Mancusi (Rome)
    Deciphering the post-translational modifications of Notch3 regulating protein activity and stability

    17:00-19:00

    Poster Session I (odd numbers) [with coffee]

    19:00-20:00

    Keynote Lecture
    Marino Zerial (Dresden, Germany)
    Self-organization and biomechanical properties of the endosomal membrane

    20:30

    Dinner

  • 9:00-10:20

    Session 2 – Cell metabolism in cancer and other diseases

    9:00-9:20

    Carmela Giachino (Catania)
    LRRK2-G2019S impacts astroglia oxidative stress, inflammatory, and metabolic response and neuron-glial communication during early post-natal development

    9:20-9:40

    Benjamin Hershey (Milan)
    Clonal collaboration through soluble factor exchange enhances the fitness of small populations of triple negative breast cancer cells

    9:40-10:00

    Mariadomenica Lupi (Candiolo, TO)
    Role of TBC1D7 in lipid metabolism in breast cancer cells

    10:00-10:20

    Agata Carreira (Trento)
    The acquirement of resistance to FK866 in triple negative breast cancer is partially mediated by the Mitochondrial Pyruvate Carrier 2 (MPC2)

    10:20-11:00

    Coffee break

    11:00-12:30

    Session 3 – Advances in cancer therapy

    11:00-11:20

    Francesca Liccardo (Rome)
    Retinoic acid synergizes with proteotoxic stress to induce cell death of FLT3-ITD+ acute myeloid leukemia progenitor cells

    11:20-11:40

    Maria Marotta (Naples)
    Novel immunogenic therapeutic combinations in anaplastic thyroid carcinoma

    11:40-12:00

    Erica Mina (Turin)
    A novel approach to target BMP-resistance in cancer cachexia skeletal muscle atrophy

    12:00-12:20

    Miriam Lucariello (Naples)
    Pharmacological targeting of the CtBP1/BARS protein in cancer and in viral infection

    12:30-12:55

    Flash Presentations II

    12:30-12:35

    Lorenzo Vaccaro (Pozzuoli, NA)
    A Perturb-seq saturation mutagenesis approach to dissect the molecular bases of genetic diseases

    12:35-12:40

    Patrizio Cracco (Rome)
    Resveratrol relies on estrogen receptor beta/neuroglobin signaling to prevent the mitochondrial dysfunction accompanying neurodegeneration

    12:40-12:45

    Antonino Cucinotta (Rome)
    Blocking the hedgehog-dependent tumor growth by a new selective endoplasmic reticulum aminopeptidase 1 inhibitor

    12:45-12:50

    Luigi D'Angelo (Bologna)
    Correlation between metabolic parameters and protein expression in ovarian cancer

    12:50-12:55

    Davide Marotta (Milan)
    Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

    13:00-14:30

    Lunch

    14:30-17:00

    Poster Session II (even numbers) [with coffee]

    17:00-18:20

    Session 4 – Epigenetic regulation in health and disease

    17:00-17:20

    Giulia Robusti (Milan)
    Integrative analysis of aberrant epigenetic features in Triple Negative Breast Cancer clinical samples

    17:20-17:40

    Vittorio Castaldo (Rome)
    Dissecting the role of miR-4443 and miR-4488 in the development of resistance to targeted therapy in metastatic melanoma

    17:40-18:00

    Marco Cimino (Modena)
    HSPB3 is a specialized chaperone that promotes myogenesis by regulating the Lamin B receptor

    18:00-18:20

    Silvia Piscitelli (Naples)
    The RNA-binding protein Lin28a: a multifunctional player in ESC differentiation

    18:30-19:30

    Keynote Lecture
    Jim Norman (Glasgow, United Kingdom)
    Tumour metabolites and exosomes exert systemic control of integrin trafficking to generate pro-invasive niches during metastasis

    20:30

    Dinner

  • 9:00-10:20

    Session 5 – Autophagy: quality control through different pathways

    9:00-9:20

    Sara Martin (Milan)
    The autophagic receptor p62 modulates micronuclei integrity

    9:20-9:40

    Sonia Viganò (Milan)
    Translationally-deficient ribosomes are actively recognised and removed in aneuploid cells

    9:40-10:00

    Martina Parente (Rome)
    Role of BET proteins as regulators of lysosomal cholesterol accumulation

    10:00-10:20

    Marianna Maddaluno (Pozzuoli, NA)
    FAM134B-mediated ER-phagy in ER-storage diseases: on the hunt for novel therapeutic approaches

    10:20-11:00

    Coffee break

    11:00-12:20

    Session 6 – Cell Cycle and stemness mechanisms

    11:00-11:20

    Eugenia Lorenzini (Reggio Emilia)
    TRIM28 is a new non-genetic dependency of Malignant Pleural Mesothelioma

    11:20-11:40

    Susanna Eli (Milan)
    Localized Wnt-sources instruct mitotic orientation: dissecting the Wnt-transduction mechanism coupled with NuMA machinery

    11:40-12:00

    Renée Duardo (Bologna)
    Unbalanced R-loops and micronuclei induced by DNA topoisomerase I poisons in cancer cells

    12:00-12:20

    Francesco Panariello (Pozzuoli, NA)
    A paracrine HGF-MET-STAT3 axis oversights cellular transition towards human pluripotency

    12:45

    Prizes for best oral presentation ("Luca Daveggio" award) and best posters

  • The poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    You are expected to have your poster up the latest by 16:30 of Thursday, 24 March. Posters should be taken down at the end of the last poster session on Friday, 25 March, the latest before dinner. Posters left behind will be removed and discarded by the venue personnel.

    N.B. Please remember to upload your poster as a PDF file through your personal myDOTT area within 11 March 2022.

    P.1 Ilenia Agliarulo (Naples)
    GRASP55 regulates localization and activity of the palmitoyltransferase DHHC16

    P.2 Sara Amiranda (Naples)
    Mutations in the protein interaction motifs of carbonic anhydrase IX alter its intracellular trafficking in hypoxic cells

    P.3 Emanuele Astoricchio (Naples)
    Ancient origins of the Golgi ribbon

    P.4 Ilaria Aurigemma (Naples)
    Defining molecular mechanisms of endothelial differentiation during the early stages of embryonic cardiopharyngeal mesoderm

    P.5 Matteo Balestra (Milan)
    Endocytic landscapes: the context dependent regulation of endocytosis

    P.6 Giulia Bartoli (Brescia)
    Molecular characterization of new variants associated with alpha-1-antitrypsin deficiency (AATD)

    P.7 Giovanna Bastari (Rome)
    Neuroglobin in non-cell-autonomous mechanism(s) of neuroprotection

    P.8 Alberto Benetollo (Padua)
    C17 corrector for the treatment of sarcoglycanopathy: preliminary ADME studies

    P.9 Caterina Boncompagni (Ferrara)
    NLRP3-mediated cardiotoxicity after radiotherapy

    P.10 Giulio Bontempi (Rome)
    Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

    P.11 Giulia Buonaiuto (Rome)
    From mouse to human: how RNA epigenetic influences cardiac and neuromuscular physiology and disease

    P.12 Barbara Carrese (Naples)
    Hybrid HSA – nanoparticles doxorubicin loaded for targeted photoacoustic imaging and chemo-thermal therapy in breast cancer

    P.13 Giuliana Cesare (Milan)
    Characterization of the function of Hecw in the autophagic pathway

    P.14 Maila Chirivì (Latina)
    Extracellular matrix stiffness promptly modulates the phenotype and gene expression of infiltrating T lymphocytes

    P.15 Marilisa Conenna (Rome)
    The role of the cytoskeleton regulator inverted formin INF2 in medulloblastoma tumorigenesis

    P.16 Veronica Consalvi (Rome)
    ERK5/MAPK is a new regulator of YAP co-transcriptional activity

    P.17 Marta Cozzi (Milan)
    Analysis of the pathogenetic mechanisms involved in KIF5A-related neurodegenerative disorders

    P.18 Patrizio Cracco (Rome)
    Resveratrol relies on estrogen receptor beta/neuroglobin signaling to prevent the mitochondrial dysfunction accompanying neurodegeneration

    P.19 Antonino Cucinotta (Rome)
    Blocking the hedgehog-dependent tumor growth by a new selective endoplasmic reticulum aminopeptidase 1 inhibitor

    P.20 Donato D'Angelo (Padua)
    Role of mitochondrial calcium in the activation and differentiation of satellite cells during skeletal muscle regeneration

    P.21 Luigi D'Angelo (Bologna)
    Correlation between metabolic parameters and protein expression in ovarian cancer

    P.22 Rossella De Florian Fania (Trieste)
    Small-molecule screening for FDA-approved drugs affecting expression levels of the tumor suppressor DAB2IP; an approach based on CRISPR/Cas9-mediated endogenous protein tagging

    P.23 Laura De Rosa (Naples)
    Early alterations of endosomal trafficking are associated with Down syndrome

    P.24 Alessandro De Santis (Rome)
    Role of non-coding RNAs in melanoma

    P.25 Victoria Stefania Del Fiore (Lecce)
    Characterization of RAB7K126R: a novel mutation in Charcot-Marie-Tooth type 2B disease

    P.26 Giorgia Di Benedetto (Naples)
    Isolation and characterization of Cardiovascular Precursor cells in Direct Cardiac Reprogramming

    P.27 Tommaso Di Mambro (Ferrara)
    Involvement of Ca2+ signaling between Endoplasmic Reticulum and Mitochondria in the cellular cycle progression and tumor proliferation

    P.28 Rosaria Di Martino (Naples)
    Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity

    P.29 Ana Belén Díaz Méndez (Rome)
    A diagnostic/prognostic serum miRNA signature negatively impacts glioma behavior

    P.30 Catiana El Kharef (Milan)
    Identification of the molecular mechanisms linking ATM to metabolic regulation

    P.31 Ben Khlifa Emna (Brescia)
    Functional characterization of amino acid variants of the reactive-center-loop of alpha-1-antitrypsin

    P.32 Antonella Esposito (Catanzaro)
    Lung adenocarcinoma cells cultured as 3D spheroids undergo a phenotypic switch associated with upregulation of antioxidant genes and resistance to ferroptosis activators

    P.33 Antonietta Esposito (Naples)
    Identification of GRASP55 contribution to the cell-contact mediated inhibition of proliferation

    P.34 Elisa Facen (Trento)
    HuR inhibitors in 2D and 3D breast cancer models

    P.35 Amir Fardin (Milan)
    The in vivo characterization of EPSIN 3 in breast cancer tumorigenesis and metastasis

    P.36 Marianna Fico (Pozzuoli, NA)
    Role of PITPNC1 at the Golgi complex

    P.37 Giuseppe Fragale (Milan)
    Tuning translation in response to mechanical stimuli

    P.38 China Genchi (Milan)
    Genetic modulation of Notch signaling: Trpm channels as novel regulators

    P.39 Stefano Gianoli (Milan)
    Sars-Cov-2 infection of human macrophages

    P.40 Luca Gozzelino (Turin)
    Defective lipid signaling caused by mutations in PIK3C2B underlies focal epilepsy

    P.41 Antonio Grimaldi (Pozzuoli, NA)
    Genomnic surveillance of COVID-19 allows the identification of new clinically relevant variants

    P.42 Maria Iavazzo (Pozzuoli, NA)
    Transcriptional control of cargo selection during autophagy

    P.43 Asrat Kahsay (Ferrara)
    Disruption of DNA methylation and mitochondrial dysfunction in pre-leukemia

    P.44 Huayi Li (Turin)
    Phosphoinositide conversion inactivates R-RAS and drives metastases in breast cancer

    P.45 Adriana Limone (Naples)
    Activation of non-canonical autophagic pathway through inhibition of non-integrin laminin receptor in neuronal cells

    P.46 Michela Lo Conte (Catanzaro)
    Identification and molecular characterization of Retinoic Acid-responsive Zinc Fingers (ZNFs) regulating self-renewal and pluripotency of human pluripotent stem cells

    P.47 Elena Loricchio (Rome)
    SALL4A promotes Hedgehog-dependent medulloblastoma by controlling HDAC1-mediated activation of GLI1

    P.48 Giorgia Maestrini (Milan)
    E-cadherin/β-catenin axis regulates myosin VI alternative splicing in colon carcinoma

    P.49 Angelica Mancusi (Rome)
    Deciphering the Post-Translational Modifications of Notch3 regulating protein activity and stability

    P.50 Giuseppe Mantova (Naples)
    The Immunoinhibitory activity of LPS from marine bacteria Echinicola pacifica KMM 6172 and Echinicola vietnamensis KMM 6221

    P.51 Francesco Marocco (Rome)
    SYNCRIP modulates the epithelial-mesenchymal transition in hepatocytes and HCC cells

    P.52 Davide Marotta (Milan)
    Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

    P.53 Valentino Martis (Milan)
    Towards a molecular understanding of aneuploid cell clearance

    P.54 Giada Mele (Monterotondo, RM)
    Characterization of human perivascular cells as a new cellular model of facioscapulohumeral muscular dystrophy

    P.55 Fatima Mentucci (Fisciano, SA)
    C/EBPβ transcription factor acts as negative regulator in IFN-γ-dependent silencing of TFF1

    P.56 Sara Milioni (Bologna)
    Adaptive responses activated upon respiratory Complex I impairment in ovarian cancer: unravelling the role of molecular players to define a novel synthetic lethality strategy

    P.57 Serena Mirata (Genoa)
    First assessment of the cytotoxic and inflammatory potential of two size-separated fractions of chrysotile asbestos fibre

    P.58 Eirini Moysidou (Milan)
    MYC-dependent transcriptional control in human lymphoma

    P.59 Pasqualina Pagano (Naples)
    Construction and screening of a repertoire of encoded immunomodulatory molecules to improve immunogenicity of Adenovirus based vaccines

    P.60 Laura Palumbo (Ferrara)
    PML-NLRP3 axis in Neuroinflammation

    P.61 Sara Pescatori (Rome)
    Clinically relevant CHEK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells

    P.62 Federica Placa (Padua)
    Mitochondrial calcium signaling in duchenne muscular dystrophy

    P.63 Pietro Poggio (Turin)
    Characterization of Morgana conditional knockout mouse model

    P.64 Lorenzo Prever (Turin)
    PI(3,4)P2-mediated cytokinetic abscission counteracts early senescence and cataract formation

    P.65 Silvia Caterina Resta (Lecce)
    Neisseria meningitidis interaction with dynein modulates the balance between apoptosis and pyroptosis

    P.66 Simona Ricciardi (Pozzuoli, NA)
    The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

    P.67 Miriam Russo (Pesche, IS)
    The BET protein inhibitor JQ1 induces autophagy and neuronal-like differentiation in glioblastoma cells

    P.68 Deborah Salvi Mesa (Milan)
    Interorganelle contact sites regulate EGFR endocytosis

    P.69 Luana Scaramuzzino (Catanzaro)
    Uncovering the function of Ferritin Heavy Chain (FTH1) in human embryonic stem cells (hESCs)

    P.70 Gianluca Scerra (Naples)
    Endoplasmic reticulum entry: the “when” matters

    P.71 Iolanda Scognamiglio (Naples)
    Breast cancer cell-derived exosomes trigger stromal fibroblasts via microRNA cargo

    P.72 Simone Scorzoni (Milan)
    Aneuploidy drives epithelial-to-mesenchymal transition

    P.73 Shaked Slovin (Pozzuoli, NA)
    An integrated screening to infer regulatory networks orchestrating human cell decisions

    P.74 Paulien Smeele (Milan)
    Snap29 modulation suppresses G4C2 toxicity in Drosophila models of C9orf72-linked amyotrophic lateral sclerosis/frontotemporal dementia

    P.75 Alessandra Spaziano (Naples)
    The role of transcription factors NRF1, NFE2 and NFE2L2 during X-Chromosome Reactivation

    P.76 Anna Maria Spera (Salerno)
    Alteration of serum lipid profiles in HIV/HCV co-infected patients under treatment with HAART/DAAs combined therapy

    P.77 Vincenzo Taibi (Milan)
    Structural insight of polyubiquitin chain formation mediated by NEDD4 HECT ligase

    P.78 Mariagrazia Talarico (Catanzaro)
    Target next-generation sequencing as a comprehensive test for genetics epilepsy

    P.79 Eleonora Tassara (Genoa)
    A study on regeneration mechanisms in early Metazoans: the effect of photobiomodulation on Porifera 

    P.81 Deborah Trastulli (Milan)
    Characterization of the molecular mechanisms involved in double stranded RNA-dependent cell death

    P.82 Silvia Trombetti (Naples)
    GATA-1 dysregulated expression contributes to energy metabolism rewiring in myeloid leukemia cells

    P.83 Lorenzo Vaccaro (Pozzuoli, NA)
    A Perturb-seq saturation mutagenesis approach to dissect the molecular bases of genetic diseases

    P.84 Valeria Valente (Naples)
    Loss of HIPK2 promotes TDP-43 protein mislocalization

    P.85 Sonia Valentini (Monterotondo, RM)
    Molecular features and efficacy of anticancer peptide in the reactivation of p53 in cancer cells

    P.86 Claudia Vilardo (Pozzuoli, NA)
    Targeting TFEB activity in Birt-Hogg-Dubè syndrome

    P.87 Vincenzo Vivenzio (Naples)
    Carbonic Anhydrases as unconventional molecular targets for generation of new antibacterial drugs

    P.88 Antonia Voli (Fisciano, SA)
    DNA methylation role in IFNγ-dependent TFF1 silencing 

    P.89 Clara Zannino (Catanzaro)
    Induced pluripotent stem cells-derived neurons as in vitro model for SCN1A related epilepsy

    P.90 Fabrizia Zevolini (Siena)
    The mitotic regulator Polo-like kinase 1 promotes cytotoxic T lymphocyte polarization

    P.91 Immacolata Zollo (Naples)
    Detection and functional characterization of an Alu insertion in the CFTR gene

    P.92 Francesca Zuppini (Turin)
    The role of extracellular co-chaperone Morgana in promoting cancer cell migration